Protection of Phytoextracts against Rotenone-Induced Organismal Toxicities in Drosophila melanogaster via the Attenuation of ROS Generation

Nutraceuticals play an essential role in the reduction free radical generation cells. A similar idea was used present study to determine effects of aqueous extracts on organismal toxicities a nontarget organism, Drosophila melanogaster, known as fruit fly. Punica granatum (peel and pulp), Carica papaya (peel), Foeniculum vulgare (seeds), Trigonella foenum-graecum Urtica dioica (leaves) were employed this study. The or behavioral rotenone-, rotenone- phytoextract-treated flies evaluated using wild-type melanogaster (Oregon R+). Reactive oxygen species (ROS) parameters (climbing ability, memory power, emergence, reproductive potential) investigated. leaves, peel, pulp elicited maximal amelioration Drosophila, although not at same intensity, all exhibited varied degree improvement different assays. Most with their potent active components (phenols, tannins, flavonoids, amino acids) revealed protective action against rotenone-induced level stated above. Interestingly, strains had tendencies. Thus, may be suitable vivo animal model for such investigations, usage phytoextracts prevent variety disorders, including neurodegeneration. results help use specific herbs reliable sources phytoingredients that useful developing nutraceuticals other clinical uses.